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PEDF-derived peptide promotes tendon regeneration through its mitogenic effect on tendon stem/progenitor cells.

Stem Cell Res Ther. 2019;

HoTsung-Chuan，TsaiShawn H，YehShu-I，ChenShow-Li，TungKwang-Yi，ChienHsin-Yu，LuYung-Chang，HuangChang-Hung，TsaoYeou-

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Peptide Synthesis	… were synthesized, modified by acetylation at the NH 2 termini and amidation at the COOH termini for stability, and characterized by mass spectrometry (> 90% purity) at GenScript (Piscataway, NJ) … 573096) were purchased from Calbiochem (La Jolla, CA, USA). Animal studies …	Get A Quote

摘要

Tendon stem/progenitor cells (TSPC) exhibit a low proliferative response to heal tendon injury， leading to limited regeneration outcomes. Exogenous growth factors that activate TSPC proliferation have emerged as a promising approach for treatment. Here， we evaluated the pigment epithelial-derived factor (PEDF)-derived short peptide (PSP; 29-mer) for treating acute tendon injury and to determine the timing and anatomical features of CD146- and necleostemin-positive TSPC in the tendon healing process.