Products/Services Used | Details | Operation |
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Catalog Antibody | GDNF family ligands (GDNF, NRTN, ARTN and PSPN) were ordered from GenScript (Z02927-1) and R&D systems (1297-NE-025/CF, 2589-AR-025/CF, 2388-PS010/CF). | Get A Quote |
Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown. Here we show that GDF15 binds specifically to GDNF family receptor α-like (GFRAL) with high affinity, and that GFRAL requires association with the coreceptor RET to elicit intracellular signaling in response to GDF15 stimulation. We also found that GDF15-mediated reductions in food intake and body weight of mice with obesity were abolished in GFRAL-knockout mice. We further found that GFRAL expression was limited to hindbrain neurons and not present in peripheral tissues, which ... More