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sIL-24 peptide， a human interleukin-24 isoform， induces mitochondrial-mediated apoptosis in human cancer cells.

Cancer Chemother. Pharmacol.. 2017-09;

ValiyariSamira, SalamiMona, MahdianReza, ShokrgozarMohammad Ali, OloomiMana, Mohammadi FarsaniAzadeh, BouzariS

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Recombinant Proteins	… Invitrogen, USA). The expressed fusion protein was purified using a Ni–NTA (nickel–nitrilotriacetic acid) column (GenScript, USA) followed by proteolytic cleavage with TEVp (Sigma, Germany) to release sIL-24. The released …	Get A Quote

摘要

Interleukin-24 (IL-24) is a unique cytokine in the IL-10 family that reveals tumor-suppressive activity against a broad range of cancers. Alternative splicing of human IL-24 generates several isoforms with different pro-apoptotic activities. In the current study， we aimed to investigate the cytotoxic properties of a recombinant smallest isoform of IL-24 (sIL-24) and the underlying molecular mechanisms in PC-3， A549， U937， and Raji cancer cells as well as normal cell line MRC-5.