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Preparation and immunogenicity of gold glyco-nanoparticles as antipneumococcal vaccine model.

Nanomedicine (Lond). 2017-01;

VetroMaria, SafariDodi, FallariniSilvia, SalsabilaKorrie, LahmannMartina, PenadésSoledad, LayLuigi, MarradiMarco, CompostellaFede

Products/Services Used	Details	Operation
Peptide Synthesis	… T-Helper ovalbumin 323–339 peptide (OVAp), derivatized at the N-terminus with an additional glycine and a mercapto-propionic acid linker, HS(CH 2 ) 2 C(O)GISQAVHAAHAEINEAGR, was obtained from GenScript Corp (NJ, USA). Preparation of GNPs …	Get A Quote

摘要

Nanotechnology-based fully synthetic carbohydrate vaccines are promising alternatives to classic polysaccharide/protein conjugate vaccines. We have prepared gold glyco-nanoparticles (GNP) bearing two synthetic carbohydrate antigens related to serotypes 19F and 14 of Streptococcus pneumoniae and evaluated their immunogenicity in vivo.