资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation.

J. Thromb. Haemost.. 2017-09;

HamadB K, PathakM, MannaR, FischerP M, EmsleyJ, Dekke

Products/Services Used	Details	Operation
Codon Optimization	… A codon-optimized CTI cDNA was obtained from Gen- Script (Piscataway, NJ, USA). High-purity-grade (> 95%) synthetic peptides were obtained from GenScript. Purity was confirmed by reverse-phase HPLC and mass spec- trometry …	Get A Quote

摘要

Essentials Corn Trypsin Inhibitor (CTI) is a selective inhibitor of coagulation Factor XII (FXII). Molecular modelling of the CTI-FXIIa complex suggested a canonical inhibitor binding mode. Mutagenesis revealed the CTI inhibitory loop and helices α1 and α2 mediate the interaction. This confirms that CTI inhibits FXII in canonical fashion and validates the molecular model.