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Mycobacterium tuberculosis proteins involved in cell wall lipid biosynthesis improve BCG vaccine efficacy in a murine TB model.

Int. J. Infect. Dis.. 2019-03;

RaoMartin, CadieuxNathalie, FitzpatrickMegan, ReedSteven, ArsenianSergei, ValentiniDavide, ParidaShreemanta, DodooErnest, ZumlaAlimuddin, MaeurerMa

Products/Services Used	Details	Operation
Catalog Antibody	… RPMI Glutamax medium, fetal bovine serum (FBS) and antibiotics for tissue culture (penicillin/streptomycin) were purchased from Life Technologies. Full-length recombinant M. tb proteins (Rv0447c, Rv2957 and Rv2958c) were purchased from GenScript (Hong Kong) …	Get A Quote

摘要

Advances in tuberculosis (TB) vaccine development are urgently required to enhance global disease management. We evaluated the potential of Mycobacterium tuberculosis (M. tb)-derived protein antigens Rv0447c， Rv2957 and Rv2958c to boost BCG vaccine efficacy in the presence or absence of glucopyranosyl lipid adjuvant formulated in a stable emulsion (GLA-SE) adjuvant.