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P15 peptide stimulates chondrogenic commitment and endochondral ossification

Int Orthop. 2017-07;

ZhangJun, EisenhauerPeter, KayaOzҫan, VaccaroAlexander R, DialloCarol, FertalaAndrzej, FreemanThere

Products/Services Used	Details	Operation
Peptide Synthesis	… A biosensor (Sensiq Pioneer, SensiQ Technologies, Inc.) was employed to analyze P15-α2β1 integrin binding interactions. For these assays, a biotinylated form of the P15 peptide was employed to facilitate its binding to the surface of a sensor chip (GenScript, Inc.) …	Get A Quote

摘要

The synthetic 15 amino acid biomimetic peptide sequence (P15) derived from a region of the alpha (α)-1 chain of collagen I， has been shown to promote α2 integrin activation and enhance intramembranous ossification. In this study， we ask if the P15 peptide also enhances bone formation through endochondral ossification， and determine if direct binding of α2 integrin with P15 mediates integrin activation.