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Peptide Synthesis | … Initial antibacterial activity screen.A total of 68 insect-derived AMPs were synthesized by solid-phase synthesis and purified by reversed-phase chromatography by GenScript (Piscataway, NJ), and the purity of the peptides was confirmed using liquid chromatography-mass … | Get A Quote |
The increasing prevalence of antibiotic resistance has created an urgent need for alternative drugs with new mechanisms of action. Antimicrobial peptides (AMPs) are promising candidates that could address the spread of multidrug-resistant bacteria, either alone or in combination with conventional antibiotics. We studied the antimicrobial efficacy and bactericidal mechanism of cecropin A2, a 36-residue α-helical cationic peptide derived from cecropin A, focusing on the common pathogen The peptide showed little hemolytic activity and toxicity toward mammalian cells, and the MICs against most clinical isolates were 32 to 64 μg/ml, and its MICs versus other Gram-negative bacteria were 2 to 32 μg/ml.... More