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Intestinal Alkaline Phosphatase Attenuates Alcohol-Induced Hepatosteatosis in Mice

Dig. Dis. Sci.. 2017-08;

HamarnehSulaiman R, KimByeong-Moo, KaliannanKanakaraju, MorrisonSara A, TantilloTyler J, TaoQingsong, MohamedMussa M Rafat, RamirezJuan M, KarasAaron, LiuWei, HuDong, TeshagerAbeba, GulSarah Shireen, EconomopoulosKonstantinos P, BhanAtul K, MaloMadhu S, ChoiMichael Y, HodinRicha

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Proteins, Expression, Isolation and Analysis	… Louis, MO) and expressed as mg/gm tissue. Limulus Amebocyte Lysate (LAL) Assay. Serum LPS concentrations were determined using a kit (GenScript, Piscataway, NJ) based on the Limulus amebocyte lysate following the manufacturer's instructions …	Get A Quote

摘要

Bacterially derived factors from the gut play a major role in the activation of inflammatory pathways in the liver and in the pathogenesis of alcoholic liver disease. The intestinal brush-border enzyme intestinal alkaline phosphatase (IAP) detoxifies a variety of bacterial pro-inflammatory factors and also functions to preserve gut barrier function. The aim of this study was to investigate whether oral IAP supplementation could protect against alcohol-induced liver disease.