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Coagulation factor XI vaccination: an alternative strategy to prevent thrombosis

J. Thromb. Haemost.. 2017-01;

ZhongC, ZhangL, ChenL, DengL

Products/Services Used	Details	Operation
Recombinant Proteins	… chromatography. Proteins were further purified with a Superdex G75 column (GE Healthcare, Piscataway, NJ, USA). The purified proteins were analyzed on 4–20% ExpressPlus PAGE gels (GenScript, Nanjing, China). Animals. Male …	Get A Quote

摘要

Essentials Coagulation Factor (F) XI is a safe target for the development of antithrombotics. We designed an antigen comprising the human FXI catalytic domain and diphtheria toxin T domain. Antigen immunization reduced plasma FXI activity by 54% and prevented thrombosis in mice. FXI vaccination can serve as an effective strategy for thrombosis prevention.