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Expression of Vitreoscilla hemoglobin enhances production of arachidonic acid and lipids in Mortierella alpina

BMC Biotechnol.. 2017-08;

ZhangHuidan, FengYingang, CuiQiu, SongXia

Products/Services Used	Details	Operation
Codon Optimization	… The vgb gene (GenBank accession no.M30794.1) of Vitreoscilla was optimized by software Optimizer (http://genomes.urv.cat/OPTIMIZER/) based on the codon preference table. The codon-optimized nucleotide sequence of vgb was synthesized by GenScript (Nanjing) Co., Ltd …	Get A Quote

摘要

Arachidonic acid (ARA， C20:4， n-6)， which belongs to the omega-6 series of polyunsaturated fatty acids and has a variety of biological activities， is commercially produced in Mortierella alpina. Dissolved oxygen or oxygen utilization efficiency is a critical factor for Mortierella alpina growth and arachidonic acid production in large-scale fermentation. Overexpression of the Vitreoscilla hemoglobin gene is thought to significantly increase the oxygen utilization efficiency of the cells.