Two paenipeptin analogues at 4 μg/ml potentiated clarithromycin and rifampin against carbapenem-resistant and strains. The combined treatment significantly increased their antibacterial efficacy in a microbiological medium and in human serum at therapeutically relevant concentrations. Moreover， these two paenipeptin analogues showed low cytotoxicity against a human kidney cell line. Therefore， combination therapy with paenipeptins may be an option for the treatment of antibiotic-resistant bacterial infections.
Two paenipeptin analogues at 4 μg/ml potentiated clarithromycin and rifampin against carbapenem-resistant and strains. The combined treatment significantly increased their antibacterial efficacy in a microbiological medium and in human serum at therapeutically relevant concentrations. Moreover， these two paenipeptin analogues showed low cytotoxicity against a human kidney cell line. Therefore， combination therapy with paenipeptins may be an option for the treatment of antibiotic-resistant bacterial infections.
