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A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus.

Mol Metab. 2018-02;

LiuShunmei，MarcelinGenevieve，BlouetClemence，JeongJae Hoon，JoYoung-Hwan，SchwartzGary J，ChuaStrea

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Peptide Synthesis	… FGF8 was resuspended in aCSF at 1 mg/ml, and mice were infused with 1 μg of the peptide via syringe pump. FGF-derived peptides (F8b13, F17b13, F8b13ProPro; sequences in Figure 6) were custom synthesized by GenScript (Piscataway, NJ) at 90% purity …	Get A Quote

摘要

Bile acids have been implicated as important regulators of glucose metabolism via activation of FXR and GPBAR1. We have previously shown that FGF19 can modulate glucose handling by suppressing the activity of hypothalamic AGRP/NPY neurons. As bile acids stimulate the release of FGF19/FGF15 into the circulation， we pursued the potential of bile acids to improve glucose tolerance via a gut-brain axis involving FXR and FGF15/FGF19 within enterocytes and FGF receptors on hypothalamic AGRP/NPY neurons.