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Combinatorial detection of autoreactive CD8 T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop.

Diabetologia. 2018-01;

JamesEddie A，AbreuJoana R F，McGintyJohn W，OdegardJared M，FilliéYvonne E，HocterClaire N，CulinaSlobodan，LadellKristin，PriceDavid A，AlkananiAimon，RihanekMarynette，Fitzgerald-MillerLisa，SkoweraAnia，SpeakeCate，GottliebPeter，DavidsonHoward W，WongF Susan，RoepBart，MalloneRobe

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Peptide Synthesis	… Characteristics of the individuals who provided samples are summarised in ESM Tables 1, 2 and 3. Peptides and HLA class I multimers. Peptides representing immunodominant beta cell and recall epitopes (Table 1) were synthesised by Genscript (Piscataway, NJ, USA) …	Get A Quote

摘要

Validated biomarkers are needed to monitor the effects of immune intervention in individuals with type 1 diabetes. Despite their importance， few options exist for monitoring antigen-specific T cells. Previous reports described a combinatorial approach that enables the simultaneous detection and quantification of multiple islet-specific CD8 T cell populations. Here， we set out to evaluate the performance of a combinatorial HLA-A2 multimer assay in a multi-centre setting.