| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Synthesis | … (Tehran, Iran). Pilocarpine hydrochloride and scopolamine methyl nitrate were procured from Sigma- Aldrich (St. Louis, MO, USA). p75 neurotrophic factor antagonist peptide was synthesized and purchased from GenScript, USA, with a minimum 92.9% purity … | Get A Quote |
Many recent epidemiological studies have shown that epileptic patients are more likely suffer from depression， anxiety， and irritability. However， the cellular mechanisms of epilepsy-induced psychotic behaviors are not fully elucidated. Neurotrophin receptors have been suggested to be involved in epilepsy and also in psychiatric disorders. Up-regulation of p75NTR expression and activation of p75NTR signalling cascades after the seizure have been shown， but the role of the p75 receptor in epilepsy-induced psychotic behaviors has not been documented so far. Therefore， the present work aimed to investigate the effect of p75 receptor blockade on seizure activity， irritability， and anxiety-like behavio... More
