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The interaction between androgen receptor and semenogelin I: a synthetic LxxLL peptide antagonist inhibits the growth of prostate cancer cells.

Br. J. Cancer. 2018-02;

LiPeng，ChenJinbo，KashiwagiEiji，MizushimaTaichi，HanBin，InoueSatoshi，IdeHiroki，IzumiKoji，MiyamotoHir

Products/Services Used	Details	Operation
Peptide Synthesis	… In addition, 18-amino acid peptides of SgI containing the LxxLL motif (wild-type: MKPNIIFVLSLLLILEKQ) or the LxxAA motif (mutant: MKPNIIFVLSLAAILEKQ) were obtained from GenScript (Piscataway, NJ, USA). Figure 1 Figure 1 …	Get A Quote

摘要

We previously demonstrated that a seminal plasma protein， semenogelin I (SgI)， functioned as an androgen receptor (AR) coactivator. Meanwhile， several short sequence motifs in AR coregulators， such as LxxLL (L=leucine)， have been shown to mediate specific interactions with AR.