| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Synthesis | … Differences were considered to be significant if P ≤ 0.05. All data were plotted in GraphPad Prism 7. No out- lier data were removed. Materials All peptides (sequences in Table 1) were synthesized and HPLC-purified (>95% purity) by Genscript Inc. (Piscataway, NJ, USA) … | Get A Quote |
N-type voltage-gated calcium (Ca 2.2) channels are critical determinants of increased neuronal excitability and neurotransmission accompanying persistent neuropathic pain. Although Ca 2.2 channel antagonists are recommended as first-line treatment for neuropathic pain， calcium-current blocking gabapentinoids inadequately alleviate chronic pain symptoms and often exhibit numerous side effects. Collapsin response mediator protein 2 (CRMP2) targets Ca 2.2 channels to the sensory neuron membrane and allosterically modulates their function. A 15-amino-acid peptide (CBD3)， derived from CRMP2， disrupts the functional protein-protein interaction between CRMP2 and Ca 2.2 channels to inhibit calcium influx， trans... More
