Products/Services Used | Details | Operation |
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Peptide Synthesis | … animals (license no. 2014-15-0201-00339). Peptides (Table 1) used in ELISA and crystallization were synthesized by WM Keck Biotechnology Resource Center (New Haven, CT) or Genscript Inc. (Paramus, NJ). The lyophilized … | Get A Quote |
Tau antibodies have shown therapeutic potential for Alzheimer's disease and several are in clinical trials. As a microtubule-associated protein, tau relies on dynamic phosphorylation for its normal functions. In tauopathies, it becomes hyperphosphorylated and aggregates into toxic assemblies, which collectively lead to neurodegeneration. Of the phospho-epitopes, the region around Ser396 has received particular attention because of its prominence and stability in tauopathies. Here we report the first structure of a monoclonal tau antibody in complex with the pathologically important phospho-Ser396 residue. Its binding region reveals tau residues Tyr394 to phospho-Ser396 stabilized in a β-strand conforma... More