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Leukotriene D4 Requires PKCα-Akt Signaling Pathway to Inhibit Na+-Dependent Alanine Cotransporter (ASCT1) in Enterocytes.

J Gastrointest Dig Syst.. 2015-01;

Jamilur R. Talukder, Jaleesa Wright, Antara Jaima,Deja McIntosh.

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Proteins, Expression, Isolation and Analysis	... 5 microscopic fields. Caspase-3 Assay A ready-to-use Caspase-3 Fluorometric Assay Kit (GenScript) was used according to manufacturer's protocol. IEC-6 cells were grown on 6-well transwell membrane. Eight days postconfluent ...	Get A Quote

摘要

Background: Varieties of inflammatory cytokines are produced during chronic enteritis including inflammatory bowel disease (IBD), that leads to malabsorption of nutrients and diarrhea. The inflammatory mediators are produced from different tissues of the body. Arachidonic acid metabolite derived via Lipoxygenase pathway, leukotriene D4 (LT) inhibits Na +-dependent alanine (Ala) cotransport (ASCT, solute carrier, slc1a4) in the apical membrane of enterocytes by decreasing the affinity of cotransporter. However, the intracellular mechanism of LT-mediated inhibition of ASCT1 activity is unknown.