Products/Services Used | Details | Operation |
---|---|---|
Proteins, Expression, Isolation and Analysis | ... For detection of IDE mRNA, primers were designed using Primer 5 software (downloaded from https://www.genscript.com/ssl-bin/app/primer) ([Table 2]). cDNA was amplified using a SYBR Premix Ex Taq kit (TaKaRa Biotechnology (Dalian) Co., Ltd.). … | Get A Quote |
Kai Xin San is a Chinese herbal formula composed of Radix Ginseng, Poria, Radix Polygalae and Acorus Tatarinowii Rhizome. It has been used in China for many years for treating amnesia. Kai Xin San ameliorates amyloid-β (Aβ)-induced cognitive dysfunction and is neuroprotective in vivo, but its precise mechanism remains unclear. Expression of insulin-degrading enzyme (IDE), which degrades Aβ, is strongly correlated with cognitive function. Here, we injected rats with exogenous Aβ42 (200 μM, 5 μL) into the hippocampus and subsequently administered Kai Xin San (0.54 or 1.08 g/kg/d) intragastrically for 21 consecutive days. Hematoxylin-eosin and Nissl staining revealed that Kai Xin San protected neurons agains... More