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Peptide Synthesis | ... Briefly, 8-week old female mice were anesthetized with isoflurane and were given a total of 200 μg of myelin oligodendrocyte glycoprotein (MOG) peptide (MOG 35–55 ; Genscript, Piscataway, NJ, USA) emulsified in Complete Freund's Adjuvant (Difco, Detroit, MI, USA ... | Get A Quote |
The ability of novel mitochondrial uncoupler prodrug of 2,4-dinitrophenol (DNP), MP201, to prevent neuronal damage and preserve visual function in an experimental autoimmune encephalomyelitis (EAE) model of optic neuritis was evaluated. Optic nerve inflammation, demyelination, and axonal loss are prominent features of optic neuritis, an inflammatory optic neuropathy often associated with the central nervous system demyelinating disease multiple sclerosis. Currently, optic neuritis is frequently treated with high-dose corticosteroids, but treatment fails to prevent permanent neuronal damage and associated vision changes that occur as optic neuritis resolves, thus suggesting that additional therapies are required... More