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RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis elegans.

Cell Cycle.. 2014-12;  13(12):1995-2009
Chu YD, Wang WC, Chen SA, Hsu YT, Yeh MW, Slack FJ, Chan SP. Graduate Institute of Microbiology; College of Medicine; National Taiwan University; Taipei, Taiwan.
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摘要

The let-7 microRNA (miRNA) regulates cell cycle exit and terminal differentiation in the C. elegans heterochronic gene pathway. Low expression of let-7 results in retarded vulva and hypodermal cell development in C. elegans and has been associated with several human cancers. Previously, the versatile scaffold protein receptor for activated C kinase 1 (RACK1) was proposed to facilitate recruitment of the miRNA-induced silencing complex (miRISC) to the polysome and to be required for miRNA function in C. elegans and humans. Here, we show that depletion of C. elegans RACK-1 by RNAi increases let-7 miRNA levels and suppresses the retarded terminal differentiation of lateral hypodermal seam cells in mutants carrying... More

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