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Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast.

Nature.. 2014-08; 
BM Zid, EK O'Shea. Howard Hughes Medical Institute, Harvard University,Cambridge, Massachusetts 02138, USA.
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摘要

A universal feature of the response to stress and nutrient limitation is transcriptional upregulation of genes that encode proteins important for survival. Under many such conditions, the overall protein synthesis level is reduced, thereby dampening the stress response at the level of protein expression. For example, during glucose starvation in Saccharomyces cerevisiae (yeast), translation is rapidly repressed, yet the transcription of many stress- and glucose-repressed genes is increased. Here we show, using ribosomal profiling and microscopy, that this transcriptionally upregulated gene set consists of two classes: one class produces messenger RNAs that are translated during glucose starvation and are diffus... More

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