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NMDA Glutamate Receptor NR1, NR2A and NR2B Expression and NR2B Tyr-1472 Phosphorylation in the Lens.

Neurochem Res.. 2014-07; 
Battacharya M, Nandanoor A, Osman M, Kasinathan C, Frederikse P. Oral Biology, Rutgers SDM, Newark, NJ, 07103, USA.
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摘要

Detailed parallels described between lens fiber cell and neuron morphology, sub-cellular structure, and molecular biology include striking similarities in the ultrastructure of their vesicle transport machinery and the membrane protrusions that occur along the lateral surfaces of both cell types. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate receptor (NMDA) glutamate receptors (AMPARs/NMDARs) are the predominant receptors in neurons. These receptors have fundamental roles in neuron morphogenesis as well as neuron physiology and dynamic cell signaling, and specifically at dendritic spines. As a result, AMPAR and NMDAR dysregulation underlies several primary neural dis... More

关键词

NMDA receptor; Tyrosine phosphorylation; AMPA receptor; Lens fiber cell; Neuron; Dendritic spine