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The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity

Authors: Kevin J Forsberg, Danica T Schmidtke, Rachel Werther, Ruben V Uribe, Deanna Hausman, Morten O A Sommer, Barry L Stoddard, Brett K Kaiser, Harmit S Malik

Journal: PLoS Biol

PubMed ID: 34644300

Doi: 10.1371/journal.pbio.3001428

Products & Services: Mutant Libraries

Kinetochore-bound Mps1 regulates kinetochore-microtubule attachments via Ndc80 phosphorylation

Authors: Krishna K Sarangapani, Lori B Koch, Christian R Nelson, Charles L Asbury, Sue Biggins

Journal: J Cell Biol

PubMed ID: 34647959

Doi: 10.1083/jcb.202106130

Products & Services: GenParts™ DNA Fragments

Metabolic adaptation drives arsenic trioxide resistance in acute promyelocytic leukemia

Authors: Nithya Balasundaram, Saravanan Ganesan, Ezhilarasi Chendamarai, Hamenth Kumar Palani, Arvind Venkatraman, Ansu Abu Alex, Sachin David, Swathy Palanikumar, Nair Reeshma Radhakrishnan, Mohammed Yasar M, Sanjeev Krishna, Anu Korula, Uday Kulkarni, Nancy Beryl Janet, Poonkuzhali Balasubramanian, Vikram Mathews

Journal: Blood Adv

PubMed ID: 34625794

Doi: 10.1182/bloodadvances.2021005300

Products & Services: PCR and Cloning

Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes

Authors: Katelyn Mika, Mirna Marinić, Manvendra Singh, Joanne Muter, Jan Joris Brosens, Vincent J Lynch

Journal: Elife

PubMed ID: 34623259

Doi: 10.7554/eLife.69584

Products & Services: Plasmid DNA Preparation

ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation

Authors: Anna Santarsiero, Paolo Convertini, Simona Todisco, Ciro L Pierri, Anna De Grassi, Niamh C Williams, Dominga Iacobazzi, Giulio De Stefano, Luke A J O'Neill, Vittoria Infantino

Journal: Cells

PubMed ID: 34831186

Doi: 10.3390/cells10112962

Products & Services: Mutant Libraries

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16

Authors: Frank Kozielski, Céleste Sele, Vladimir O Talibov, Jiaqi Lou, Danni Dong, Qian Wang, Xinyue Shi, Maria Nyblom, Annika Rogstam, Tobias Krojer, Zoë Fisher, Wolfgang Knecht

Journal: RSC Chem Biol

PubMed ID: 35128408

Doi: 10.1039/d1cb00135c

Products & Services: Bacterial Expression

Effects of Distal Mutations on Ligand-Binding Affinity in Dihydrofolate Reductase

Authors: Chen-Hua Huang, Yun-Wen Chen, Tsun-Tsao Huang, Ya-Ting Kao

Journal: ACS Omega

PubMed ID: 34660967

Doi: 10.1021/acsomega.1c02995

Products & Services: Plasmid DNA Preparation

Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes

Authors: Yingying Liu, Samantha Gokhale, Jaeyong Jung, Sining Zhu, Chang Luo, Debanjan Saha, Jessie Yanxiang Guo, Huaye Zhang, Saw Kyin, Wei-Xing Zong, Eileen White, Ping Xie

Journal: Front Immunol

PubMed ID: 34745083

Doi: 10.3389/fimmu.2021.670338

Products & Services: DNA Sequencing

Synergistic anti-inflammatory activity of apigenin and curcumin co-encapsulated in caseins assessed with lipopolysaccharide-stimulated RAW 2647 macrophages

Authors: Shan Hong, Vermont P Dia, Qixin Zhong

Journal: Int J Biol Macromol

PubMed ID: 34717976

Doi: 10.1016/j.ijbiomac.2021.10.153

Products & Services: Proteins, Expression, Isolation and Analysis

Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome

Authors: Liangli Jin, Quanyi Li, Jing Li, Yang Pan, Jue Zou, Xiaoyuan Wu, Zhi Wang