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至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

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The B-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5'-deoxyadenosine and not 5'-deoxy-5'-(methylthio)adenosine

Authors: William G Walls, James D Moody, Elizabeth C McDaniel, Maria Villanueva, Eric M Shepard, William E Broderick, Joan B Broderick

Journal: J Inorg Biochem

PubMed ID: 34847521

Doi: 10.1016/j.jinorgbio.2021.111662

Products & Services: Codon Optimization

Purification of an insect juvenile hormone receptor complex enables insights into its post-translational phosphorylation

Authors: Marek Jindra, William J McKinstry, Thomas Nebl, Lenka Bittova, Bin Ren, Jan Shaw, Tram Phan, Louis Lu, Jason K K Low, Joel P Mackay, Lindsay G Sparrow, George O Lovrecz, Ronald J Hill

Journal: J Biol Chem

PubMed ID: 34758356

Doi: 10.1016/j.jbc.2021.101387

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New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products

Authors: Julia K Lewis, Andrew S Jochimsen, Sarah J Lefave, Anthony P Young, William M Kincannon, Andrew G Roberts, Matthew T Kieber-Emmons, Vahe Bandarian

Journal: Biochemistry

PubMed ID: 34730336

Doi: 10.1021/acs.biochem.1c00469

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In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI-MS spectrum

Authors: Luis Ariel Espinosa, Yassel Ramos, Ivan Andújar, Enso Onill Torres, Gleysin Cabrera, Alejandro Martín, Diamilé Roche, Glay Chinea, Mónica Becquet, Isabel González, Camila Canaán-Haden, Elías Nelson, Gertrudis Rojas, Beatriz Pérez-Massón, Dayana Pérez-Martínez, Tamy Boggiano, Julio Palacio, Sum Lai Lozada Chang, Lourdes Hernández, Kathya Rashida de la Luz Hernández, Saloheimo Markku, Marika Vitikainen, Yury Valdés-Balbín, Darielys Santana-Medero, Daniel G Rivera, Vicente Vérez-Bencomo, Mark Emalfarb, Ronen Tchelet, Gerardo Guillén, Miladys Limonta, Eulogio Pimentel, Marta Ayala, Vladimir Besada, Luis Javier González

Journal: Anal Bioanal Chem

PubMed ID: 34739558

Doi: 10.1007/s00216-021-03721-w

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Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant

Authors: Bassel Akache, Tyler M Renner, Anh Tran, Lise Deschatelets, Renu Dudani, Blair A Harrison, Diana Duque, Julie Haukenfrers, Martin A Rossotti, Francis Gaudreault, Usha D Hemraz, Edmond Lam, Sophie Régnier, Wangxue Chen, Christian Gervais, Matthew Stuible, Lakshmi Krishnan, Yves Durocher, Michael J McCluskie

Journal: Sci Rep

PubMed ID: 34750472

Doi: 10.1038/s41598-021-01363-7

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Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations

Authors: Barbora Novotná, Lucie Holá, Monika Staś, Ondrej Gutten, Miroslav Smola, Martin Zavřel, Zdeněk Vavřina, Miloš Buděšínský, Radek Liboska, Florian Chevrier, Juraj Dobiaš, Evzen Boura, Lubomír Rulíšek, Gabriel Birkuš

Journal: Biochemistry

PubMed ID: 34788017

Doi: 10.1021/acs.biochem.1c00692

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Two C1-oxidizing AA9 lytic polysaccharide monooxygenases from Sordaria brevicollis differ in thermostability, activity, and synergy with cellulase

Authors: Xi Zhang, Kaixiang Chen, Liangkun Long, Shaojun Ding

Journal: Appl Microbiol Biotechnol

PubMed ID: 34748039

Doi: 10.1007/s00253-021-11677-1

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Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Authors: Mark Yarmarkovich, Quinlen F Marshall, John M Warrington, Rasika Premaratne, Alvin Farrel, David Groff, Wei Li, Moreno di Marco, Erin Runbeck, Hau Truong, Jugmohit S Toor, Sarvind Tripathi, Son Nguyen, Helena Shen, Tiffany Noel, Nicole L Church, Amber Weiner, Nathan Kendsersky, Dan Martinez, Rebecca Weisberg, Molly Christie, Laurence Eisenlohr, Kristopher R Bosse, Dimiter S Dimitrov, Stefan Stevanovic, Nikolaos G Sgourakis, Ben R Kiefel, John M Maris

Journal: Nature

PubMed ID: 34732890

Doi: 10.1038/s41586-021-04061-6

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Potentiality of Melittin-Loaded Niosomal Vesicles Against Vancomycin-Intermediate and Staphylococcal Skin Infection

Authors: Sirikwan Sangboonruang, Natthawat Semakul, Mohammad A Obeid, Marta Ruano, Kuntida Kitidee, Usanee Anukool, Kidsadagon Pringproa, Panuwan Chantawannakul, Valerie A Ferro, Yingmanee Tragoolpua, Khajornsak Tragoolpua

Journal: Int J Nanomedicine

PubMed ID: 34819727

Doi: 10.2147/IJN.S325901

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Multifunctional Dendronized Polypeptides for Controlled Adjuvanticity

Authors: Zhiyuan Fan, Sharon Jan, James C Hickey, D Huw Davies, Jiin Felgner, Philip L Felgner, Zhibin Guan

Journal: Biomacromolecules

PubMed ID: 34788023

Doi: 10.1021/acs.biomac.1c01052

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