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CRISPR/Cas9-Based Mutagenesis of Histone H31 in Spinal Dynorphinergic Neurons Attenuates Thermal Sensitivity in Mice

Authors: Zoltán Mészár, Éva Kókai, Rita Varga, László Ducza, Tamás Papp, Monika Béresová, Marianna Nagy, Péter Szücs, Angelika Varga

Journal: Int J Mol Sci

PubMed ID: 35328599

Doi: 10.3390/ijms23063178

Products & Services: Custom Vector Construction

Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling

Authors: Kelly J Culhane, Tejas M Gupte, Indrani Madhugiri, Chetan J Gadgil, Sivaraj Sivaramakrishnan

Journal: Nat Commun

PubMed ID: 35260563

Doi: 10.1038/s41467-022-28789-5

Products & Services: Catalog Peptides

Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models

Authors: Giuseppe Palladino, Cheng Chang, Changkeun Lee, Nedzad Music, Ivna De Souza, Jonathan Nolasco, Samuel Amoah, Pirada Suphaphiphat, Gillis R Otten, Ethan C Settembre, Yingxia Wen

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35345593

Doi: 10.1016/j.omtm.2022.03.013

Products & Services: Mammalian Expression

Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY

Authors: Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii

Journal: Protein Expr Purif

PubMed ID: 35307559

Doi: 10.1016/j.pep.2022.106089

Products & Services: PCR Cloning and Subcloning

Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production

Authors: Jin Zhao, Jiaoshan Chen, Congcong Wang, Yajie Liu, Minchao Li, Yanjun Li, Ruiting Li, Zirong Han, Junjian Wang, Ling Chen, Yuelong Shu, Genhong Cheng, Caijun Sun

Journal: PLoS Pathog

PubMed ID: 35235615

Doi: 10.1371/journal.ppat.1010366

Products & Services: Catalog Peptides

Insight into Cellular Uptake and Transcytosis of Peptide Nanoparticles in Cells and Isolated Midgut

Authors: Erin McGraw, Jonathan D Roberts, Nitish Kunte, Matthew Westerfield, Xavier Streety, David Held, L Adriana Avila

Journal: ACS Omega

PubMed ID: 35415340

Doi: 10.1021/acsomega.1c06638

Products & Services: Molecular Biology Tools

Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations

Authors: Zheng Fang Yang, Pankaj Panwar, Ciaran R McFarlane, Wietske E Tuinte, Marta Campiglio, Filip Van Petegem