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The Breadth and Molecular Basis of Hcp-Driven Type VI Secretion System Effector Delivery
Authors: Sophie A Howard, R Christopher D Furniss, Dora Bonini, Himani Amin, Patricia Paracuellos, David Zlotkin, Tiago R D Costa, Asaf Levy, Despoina A I Mavridou, Alain Filloux
Journal: MBio
PubMed ID: 34061601
Doi: 10.1128/mBio.00262-21
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Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells
Authors: Carmen Aguilar, Susana Costa, Claire Maudet, R P Vivek-Ananth, Sara Zaldívar-López, Juan J Garrido, Areejit Samal, Miguel Mano, Ana Eulalio
Journal: Nat Commun
PubMed ID: 34099666
Doi: 10.1038/s41467-021-23593-z
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An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo
Authors: Xulun Zhang, Can Martin Zhang, Dmitry Prokopenko, Yingxia Liang, Sherri Y Zhen, Ian Q Weigle, Weinong Han, Manish Aryal, Rudolph E Tanzi, Sangram S Sisodia
Journal: J Exp Med
PubMed ID: 33822840
Doi: 10.1084/jem.20210313
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Reduced mGluR5 Activity Modulates Mitochondrial Function
Authors: Miguel A Gonzalez-Lozano, Joke Wortel, Rolinka J van der Loo, Jan R T van Weering, August B Smit, Ka Wan Li
Journal: Cells
PubMed ID: 34199502
Doi: 10.3390/cells10061375
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A Rapid Assay for SARS-CoV-2 Neutralizing Antibodies That Is Insensitive to Antiretroviral Drugs
Authors: Deli Huang, Jenny Tuyet Tran, Linghang Peng, Linlin Yang, Raymond T Suhandynata, Melissa A Hoffman, Fangzhu Zhao, Ge Song, Wan-Ting He, Oliver Limbo, Sean Callaghan, Elise Landais, Raiees Andrabi, Devin Sok, Joseph G Jardine, Dennis R Burton, James E Voss, Robert L Fitzgerald, David Nemazee
Journal: J Immunol
PubMed ID: 34183368
Doi: 10.4049/jimmunol.2100155
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CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B1351 SARS-CoV-2
Authors: Donata Hoffmann, Björn Corleis, Susanne Rauch, Nicole Roth, Janine Mühe, Nico Joel Halwe, Lorenz Ulrich, Charlie Fricke, Jacob Schön, Anna Kraft, Angele Breithaupt, Kerstin Wernike, Anna Michelitsch, Franziska Sick, Claudia Wylezich, Bernd Hoffmann, Moritz Thran, Andreas Thess, Stefan O Mueller, Thomas C Mettenleiter, Benjamin Petsch, Anca Dorhoi, Martin Beer
Journal: Nat Commun
PubMed ID: 34193869
Doi: 10.1038/s41467-021-24339-7
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SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques
Authors: Carolina Garrido, Alan D Curtis, Maria Dennis, Sachi H Pathak, Hongmei Gao, David Montefiori, Mark Tomai, Christopher B Fox, Pamela A Kozlowski, Trevor Scobey, Jennifer E Munt, Michael L Mallory, Pooja T Saha, Michael G Hudgens, Lisa C Lindesmith, Ralph S Baric, Olubukola M Abiona, Barney Graham, Kizzmekia S Corbett, Darin Edwards, Andrea Carfi, Genevieve Fouda, Koen K A Van Rompay, Kristina De Paris, Sallie R Permar
Journal: Sci Immunol
PubMed ID: 34131024
Doi: 10.1126/sciimmunol.abj3684
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Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX
Authors: Jiajia Ma, Claire A Scott, Ying Na Ho, Harsha Mahabaleshwar, Katherine S Marsay, Changqing Zhang, Christopher Kj Teow, Ser Sue Ng, Weibin Zhang, Vinay Tergaonkar, Lynda J Partridge, Sudipto Roy, Enrique Amaya, Tom J Carney
Journal: Elife
PubMed ID: 34165081
Doi: 10.7554/eLife.66596
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Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y12 signaling pathway
Authors: Huang B, Qian Y, Xie S, Ye X, Chen H, Chen Z, Zhang L, Xu J, Hu H, Ma S, Héroux P, Wang D, Shen HM, Wu Y, Xia D
Journal: Cellular & molecular immunology
PubMed ID: 32523112
Doi: 10.1038/s41423-020-0444-5
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Open stomata 1 exhibits dual serine/threonine and tyrosine kinase activity in regulating ABA signaling
Authors: Yun Shang, Dami Yang, Yunmi Ha, Ju Yeon Lee, Jin Young Kim, Man-Ho Oh, Kyoung Hee Nam
Journal: J Exp Bot
PubMed ID: 34021330
Doi: 10.1093/jxb/erab225
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