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A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.
Authors: SoChun,SeresK Bianka,SteyerAnna M,M?nnichEike,CliftDean,PejkovskaAnastasija,M?biusWiebke,SchuhMe
Journal: Science
PubMed ID: 31249032
Doi: 10.1126/science.aat9557
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Tau local structure shields an?amyloid-forming motif and controls aggregation propensity.
Authors: ChenDailu,DromboskyKenneth W,HouZhiqiang,SariLevent,KashmerOmar M,RyderBryan D,PerezValerie A,WoodardDaNae R,LinMilo M,DiamondMarc I,JoachimiakLuka
Journal: Nat Commun
PubMed ID: 31175300
Doi: 10.1038/s41467-019-10355-1
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The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif.
Authors: ChenMo,ChoiSuyong,JungOisun,WenTianmu,BaumChristina,ThapaNarendra,LambertPaul F,RapraegerAlan C,AndersonRicha
Journal: Sci Rep
PubMed ID: 31235839
Doi: 10.1038/s41598-019-45671-5
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Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.
Authors: ShenKoning,GamerdingerMartin,ChanRebecca,GenseKarina,MartinEsther M,SachsNadine,KnightPatrick D,SchlömerRenate,CalabreseAntonio N,StewartKatie L,LeiendeckerLukas,BaghelAnkit,RadfordSheena E,FrydmanJudith,Deuerling
Journal: Mol. Cell
PubMed ID: 30982745
Doi: 10.1016/j.molcel.2019.03.012
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Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin.
Authors: YeLiang,SchnepfDaniel,BeckerJan,EbertKarolina,TanriverYakup,BernasconiValentina,GadHans Henrik,HartmannRune,LyckeNils,StaeheliP
Journal: Nat. Immunol.
PubMed ID: 30886417
Doi: 10.1038/s41590-019-0345-x
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CGRP signalling inhibits NO production through pannexin-1 channel activation in endothelial cells.
Authors: GaetePablo S,LilloMauricio A,PueblaMariela,PobleteInés,FigueroaXavi
Journal: Sci Rep
PubMed ID: 31138827
Doi: 10.1038/s41598-019-44333-w
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Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer's disease.
Authors: TaoChih-Chieh,ChengKuang-Min,MaYun-Li,HsuWei-Lun,ChenYan-Chu,FuhJong-Ling,LeeWei-Ju,ChaoChih-Chang,LeeEminy
Journal: Cell Death Differ
PubMed ID: 31127200
Doi: 10.1038/s41418-019-0348-z
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Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance.
Authors: LancasterJ N,ThyagarajanH M,SrinivasanJ,LiY,HuZ,EhrlichL
Journal: Nat Commun
PubMed ID: 31101805
Doi: 10.1038/s41467-019-09727-4
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Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy.
Authors: Perez-RuizElisabeth,MinuteLuna,OtanoItziar,AlvarezMaite,OchoaMaria Carmen,BelsueVirginia,de AndreaCarlos,Rodriguez-RuizMaria Esperanza,Perez-GraciaJose Luis,Marquez-RodasIvan,LlacerCasilda,AlvarezMartina,de LuqueVanesa,MolinaCarmen,TeijeiraAlvaro,BerraondoPedro,MeleroIgn
Journal: Nature
PubMed ID: 31043740
Doi: 10.1038/s41586-019-1162-y
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Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.
Authors: BellScott,RousseauJustine,PengHuashan,AouabedZahia,PriamPierre,TherouxJean-Francois,JefriMalvin,TantiArnaud,WuHanrong,KolobovaIlaria,SilvieraHeika,Manzano-VargasKarla,EhresmannSophie,HamdanFadi F,HettigeNuwan,ZhangXin,AntonyanLilit,NassifChristina,Ghaloul-GonzalezLina,SebastianJessica,VockleyJerry,BegtrupAmber G,WentzensenIngrid M,CrunkAmy,NichollsRobert D,HermanKristin C,DeignanJoshua L,Al-HertaniWalla,EfthymiouStephanie,SalpietroVincenzo,MiyakeNoriko,MakitaYoshio,MatsumotoNaomichi,?sternRune,HougeGunnar,Hafstr?mMaria,FassiEmily,HouldenHenry,Klein Wassink-RuiterJolien S,NelsonDominic,GoldsteinAmy,DabirTabib,van GilsJulien,BourgeronThomas,DelormeRichard,CooperGregory M,MartinezJose E,FinnilaCandice R,CarmantLionel,LortieAnne,OegemaRenske,van GassenKoen,MehtaSarju G,HuhleDagmar,Abou JamraRami,MartinSonja,BrunnerHan G,LindhoutDick,AuMargaret,GrahamJohn M,CoubesChristine,TureckiGustavo,GravelSimon,MechawarNaguib,RossignolElsa,MichaudJacques L,LessardJulie,ErnstCarl,CampeauPhilip
Journal: Am J Hum Genet
PubMed ID: 31031012
Doi: 10.1016/j.ajhg.2019.03.022
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